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NEWS
Tiny Tooth-Mounted Sensors Developed
May 15, 2018

Monitoring in real time what happens in and around our bodies can be invaluable in the context of health care or clinical studies, but not so easy to do. According to information provided by the Tufts University School of Engineering (Tufts), that could soon change thanks to new, miniaturized sensors developed by researchers at Tufts that, when mounted directly on a tooth and communicating wirelessly with a mobile device, can transmit information on glucose, salt and alcohol intake. In research, “Functional, RF-trilayer sensors for tooth-mounted, wireless monitoring of the oral cavity and food consumption,” to be published in the journal Advanced Materials, researchers note that future adaptations of these sensors could enable the detection and recording of a wide range of nutrients, chemicals and physiological states.


Tiny sensor mounted on a tooth detects nutrients and other chemicals. Credit: Silklab, Tufts University.

Previous wearable devices for monitoring dietary intake suffered from limitations such as requiring the use of a mouth guard, bulky wiring, or necessitating frequent replacement as the sensors rapidly degraded. Tufts engineers sought a more adoptable technology and developed a sensor with a mere 2mm x 2mm footprint that can flexibly conform and bond to the irregular surface of a tooth. In a similar fashion to the way a toll is collected on a highway, the sensors transmit their data wirelessly in response to an incoming radiofrequency signal.

The sensors are made up of three sandwiched layers: a central “bioresponsive” layer that absorbs the nutrient or other chemicals to be detected, and outer layers consisting of two square-shaped gold rings. Together, the three layers act like a tiny antenna, collecting and transmitting waves in the radiofrequency spectrum. As an incoming wave hits the sensor, some of it is cancelled out and the rest transmitted back, just like a patch of blue paint absorbs redder wavelengths and reflects the blue back to our eyes.

The sensor, however, can change its “color.” For example, if the central layer takes on salt, or ethanol, its electrical properties will shift, causing the sensor to absorb and transmit a different spectrum of radiofrequency waves, with varying intensity. That is how nutrients and other analytes can be detected and measured.

“In theory we can modify the bioresponsive layer in these sensors to target other chemicals – we are really limited only by our creativity,” said Fiorenzo Omenetto, Ph.D., corresponding author and the Frank C. Doble Professor of Engineering at Tufts. “We have extended common RFID [radio frequency ID] technology to a sensor package that can dynamically read and transmit information on its environment, whether it is affixed to a tooth, to skin, or any other surface.”

The work was supported by U.S. Army Natick Soldier Research, Development and Engineering Center, the National Institutes of Health National Institute of Biomedical Imaging and Bioengineering, and the Office of Naval Research.


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